FIGN Antibody, Biotin conjugated

Code CSB-PA008676LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FIGN Polyclonal antibody
Uniprot No.
Target Names
FIGN
Alternative Names
FIGNFidgetin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Fidgetin protein (132-371AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.
Gene References into Functions
  1. FIGN might play an important role in decreased congenital heart defect risk by upregulating plasma folate concentration during embryo heart development PMID: 28534241
  2. FIGN +94762G>C polymorphism reduced the risk of congenital heart defects by activating the transcription of an alternative FIGN isoform, inhibiting proteasome activity and allowing the accumulation of RFC1 and DHFR, promoting folate transmembrane transport and utilization. PMID: 28302752
  3. The loss of Fidgetin induces a microtubule-dependent enlargement of mitotic centrosomes and an increase in the number and length of astral microtubules. PMID: 22672901
Subcellular Location
Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
Protein Families
AAA ATPase family
Database Links

HGNC: 13285

OMIM: 605295

KEGG: hsa:55137

STRING: 9606.ENSP00000333836

UniGene: Hs.593650

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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